USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: HS90B_HUMAN USC-OGP 2-DE database:  HS90B_HUMAN HS90B_HUMAN General information about the entry View entry in simple text format Entry name HS90B_HUMAN Primary accession number P08238 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Heat shock protein HSP 90-beta; Short=HSP 90; AltName: Full=Heat shock 84 kDa; Short=HSP 84; Short=HSP84;. Gene name Name=HSP90AB1 Synonyms=HSP90B, HSPC2, HSPCB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0046: pI=4.80; Mw=56520 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1111: pI=5.20; Mw=104418 Cross-references UniProtKB/Swiss-Prot P08238; HS90B_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name HS90B_HUMAN Primary accession number P08238 Secondary accession number(s) B2R5P0 Q5T9W7 Q9NQW0 Q9NTK6 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 218) Name and origin of the protein Description RecName: Full=Heat shock protein HSP 90-beta; Short=HSP 90; AltName: Full=Heat shock 84 kDa; Short=HSP 84; Short=HSP84; Gene name Name=HSP90AB1 Synonyms=HSP90B, HSPC2, HSPCB Encoded on Name=HSP90AB1; Synonyms=HSP90B, HSPC2, HSPCB Keywords 3D-structure; Acetylation; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; S-nitrosylation; Stress response; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M16660; AAA36025.1; -; mRNA EMBL J04988; AAA36026.1; -; Genomic_DNA EMBL AY359878; AAQ63401.1; -; mRNA EMBL AL136543; CAB66478.1; ALT_FRAME; mRNA EMBL AK312255; BAG35187.1; -; mRNA EMBL DQ314872; ABC40731.1; -; Genomic_DNA EMBL AL139392; CAI20095.1; -; Genomic_DNA EMBL CH471081; EAX04257.1; -; Genomic_DNA EMBL BC004928; AAH04928.1; -; mRNA EMBL BC009206; AAH09206.2; -; mRNA EMBL BC012807; AAH12807.1; -; mRNA EMBL BC014485; AAH14485.1; -; mRNA EMBL BC016753; AAH16753.1; -; mRNA EMBL BC068474; AAH68474.1; -; mRNA EMBL AH007358; AAD14062.3; ALT_INIT; Genomic_DNA EMBL AF275719; AAF82792.1; -; mRNA CCDS CCDS4909.1; -; . PIR A29461; HHHU84; . PIR T46243; T46243; . RefSeq NP_001258898.1; NM_001271969.1; . RefSeq NP_001258899.1; NM_001271970.1; . RefSeq NP_001258900.1; NM_001271971.1; . RefSeq NP_031381.2; NM_007355.3; . UniGene Hs.509736; -; . PDB 1QZ2; X-ray; 3.00 A; G/H=720-724 PDB 1UYM; X-ray; 2.45 A; A=2-221 PDB 2L6J; NMR; -; B=720-724 PDB 3FWV; X-ray; 2.20 A; C/D=719-723 PDB 3NMQ; X-ray; 2.20 A; A=1-223 PDB 3PRY; X-ray; 2.28 A; A/B/C=284-543 PDB 3UQ3; X-ray; 2.60 A; B/C=720-724 PDB 5FWK; EM; 3.90 A; A/B=1-724 PDB 5FWL; EM; 9.00 A; A/B=1-724 PDB 5FWM; EM; 8.00 A; A/B=1-724 PDB 5FWP; EM; 7.20 A; A/B=1-724 PDBsum 1QZ2; -; . PDBsum 1UYM; -; . PDBsum 2L6J; -; . PDBsum 3FWV; -; . PDBsum 3NMQ; -; . PDBsum 3PRY; -; . PDBsum 3UQ3; -; . PDBsum 5FWK; -; . PDBsum 5FWL; -; . PDBsum 5FWM; -; . PDBsum 5FWP; -; . ProteinModelPortal P08238; -; . SMR P08238; -; . BioGrid 109558; 314; . DIP DIP-413N; -; . IntAct P08238; 522; . MINT MINT-99712; -; . STRING 9606.ENSP00000325875; -; . BindingDB P08238; -; . ChEMBL CHEMBL4303; -; . DrugBank DB05134; CNF1010; . DrugBank DB02424; Geldanamycin; . DrugBank DB03758; Radicicol; . DrugBank DB06070; SNX-5422; . GuidetoPHARMACOLOGY 2907; -; . iPTMnet P08238; -; . PhosphoSitePlus P08238; -; . SwissPalm P08238; -; . DMDM 17865718; -; . OGP P08238; -; . EPD P08238; -; . MaxQB P08238; -; . PaxDb P08238; -; . PeptideAtlas P08238; -; . PRIDE P08238; -; . TopDownProteomics P08238; -; . DNASU 3326; -; . Ensembl ENST00000353801; ENSP00000325875; ENSG00000096384; . Ensembl ENST00000371554; ENSP00000360609; ENSG00000096384; . Ensembl ENST00000371646; ENSP00000360709; ENSG00000096384; . Ensembl ENST00000620073; ENSP00000481908; ENSG00000096384; . GeneID 3326; -; . KEGG hsa:3326; -; . UCSC uc003oxa.3; human; . CTD 3326; -; . DisGeNET 3326; -; . GeneCards HSP90AB1; -; . H-InvDB HIX0031498; -; . H-InvDB HIX0057380; -; . HGNC HGNC:5258; HSP90AB1; . HPA CAB005230; -; . HPA HPA055729; -; . MIM 140572; gene; . neXtProt NX_P08238; -; . OpenTargets ENSG00000096384; -; . PharmGKB PA29524; -; . eggNOG KOG0019; Eukaryota; . eggNOG KOG0020; Eukaryota; . eggNOG COG0326; LUCA; . GeneTree ENSGT00840000129758; -; . HOGENOM HOG000031988; -; . HOVERGEN HBG007374; -; . InParanoid P08238; -; . KO K04079; -; . OMA AFANDIC; -; . OrthoDB EOG091G0270; -; . PhylomeDB P08238; -; . TreeFam TF300686; -; . Reactome R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; . Reactome R-HSA-3371511; HSF1 activation; . Reactome R-HSA-3371568; Attenuation phase; . Reactome R-HSA-3371571; HSF1-dependent transactivation; . Reactome R-HSA-399954; Sema3A PAK dependent Axon repulsion; . Reactome R-HSA-5336415; Uptake and function of diphtheria toxin; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-844456; The NLRP3 inflammasome; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8937144; Aryl hydrocarbon receptor signalling; . SIGNOR P08238; -; . ChiTaRS HSP90AB1; human; . EvolutionaryTrace P08238; -; . GeneWiki HSP90AB1; -; . GenomeRNAi 3326; -; . PRO PR:P08238; -; . Proteomes UP000005640; Chromosome 6; . Bgee ENSG00000096384; -; . CleanEx HS_HSP90AB1; -; . ExpressionAtlas P08238; baseline and differential; . Genevisible P08238; HS; . GO GO:0016324; C:apical plasma membrane; IEA:Ensembl; . GO GO:0034751; C:aryl hydrocarbon receptor complex; IDA:UniProtKB; . GO GO:0016323; C:basolateral plasma membrane; IEA:Ensembl; . GO GO:0031526; C:brush border membrane; IEA:Ensembl; . GO GO:0009986; C:cell surface; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0016234; C:inclusion body; IEA:Ensembl; . GO GO:0005765; C:lysosomal membrane; IEA:Ensembl; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:1990917; C:ooplasm; IEA:Ensembl; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:1990913; C:sperm head plasma membrane; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0002135; F:CTP binding; IEA:Ensembl; . GO GO:0032564; F:dATP binding; IEA:Ensembl; . GO GO:0070182; F:DNA polymerase binding; IPI:BHF-UCL; . GO GO:0003725; F:double-stranded RNA binding; IDA:MGI; . GO GO:0008144; F:drug binding; IEA:Ensembl; . GO GO:0005525; F:GTP binding; IEA:Ensembl; . GO GO:0031072; F:heat shock protein binding; IPI:UniProtKB; . GO GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; . GO GO:1990226; F:histone methyltransferase binding; IPI:UniProtKB; . GO GO:0019900; F:kinase binding; IPI:UniProtKB; . GO GO:0023026; F:MHC class II protein complex binding; IDA:UniProtKB; . GO GO:0030235; F:nitric-oxide synthase regulator activity; ISS:UniProtKB; . GO GO:0046983; F:protein dimerization activity; IDA:UniProtKB; . GO GO:0019887; F:protein kinase regulator activity; IEA:Ensembl; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0030911; F:TPR domain binding; ISS:UniProtKB; . GO GO:0002134; F:UTP binding; IEA:Ensembl; . GO GO:0035690; P:cellular response to drug; IEA:Ensembl; . GO GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl; . GO GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IEA:Ensembl; . GO GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl; . GO GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0001890; P:placenta development; IEA:Ensembl; . GO GO:0045597; P:positive regulation of cell differentiation; IMP:UniProtKB; . GO GO:0045793; P:positive regulation of cell size; IEA:Ensembl; . GO GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:UniProtKB; . GO GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IDA:UniProtKB; . GO GO:0032092; P:positive regulation of protein binding; IEA:Ensembl; . GO GO:0033160; P:positive regulation of protein import into nucleus; translocation; IEA:Ensembl GO GO:2000010; P:positive regulation of protein localization to cell surface; IDA:UniProtKB; . GO GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl; . GO GO:0051973; P:positive regulation of telomerase activity; IDA:BHF-UCL; . GO GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB; . GO GO:0006457; P:protein folding; IEA:InterPro; . GO GO:0050821; P:protein stabilization; TAS:Reactome; . GO GO:1900034; P:regulation of cellular response to heat; TAS:Reactome; . GO GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; IMP:MGI; . GO GO:0031396; P:regulation of protein ubiquitination; IDA:BHF-UCL; . GO GO:0060338; P:regulation of type I interferon-mediated signaling pathway; IMP:MGI; . GO GO:0042220; P:response to cocaine; IEA:Ensembl; . GO GO:0009651; P:response to salt stress; IEA:Ensembl; . GO GO:0006986; P:response to unfolded protein; NAS:UniProtKB; . GO GO:0097435; P:supramolecular fiber organization; IMP:CACAO; . GO GO:1905323; P:telomerase holoenzyme complex assembly; IDA:BHF-UCL; . GO GO:0007004; P:telomere maintenance via telomerase; IDA:BHF-UCL; . GO GO:0019062; P:virion attachment to host cell; IMP:CACAO; . GO GO:0006805; P:xenobiotic metabolic process; TAS:Reactome; . Gene3D 3.30.565.10; -; 2; . HAMAP MF_00505; HSP90; 1; . InterPro IPR003594; HATPase_C; . InterPro IPR019805; Heat_shock_protein_90_CS; . InterPro IPR001404; Hsp90_fam; . InterPro IPR020575; Hsp90_N; . InterPro IPR020568; Ribosomal_S5_D2-typ_fold; . PANTHER PTHR11528; PTHR11528; 1; . Pfam PF02518; HATPase_c; 1; . Pfam PF00183; HSP90; 1; . PIRSF PIRSF002583; Hsp90; 1; . PRINTS PR00775; HEATSHOCK90; . SMART SM00387; HATPase_c; 1; . SUPFAM SSF54211; SSF54211; 1; . SUPFAM SSF55874; SSF55874; 1; . PROSITE PS00298; HSP90; 1; .

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